Drug interactions
Cyclophosphamide + Dalteparin
Severity: Moderate
Cyclophosphamide and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide can cause thrombocytopenia, which raises bleeding risk in patients receiving the low molecular weight heparin dalteparin. The problem results from combined effects on hemostasis rather than a direct drug interaction.
What this interaction means in plain words
Cyclophosphamide and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Dalteparin belongs to Cardiovascular.
Why it happens
Chemotherapy-induced thrombocytopenia adds to the anticoagulant effect of dalteparin.
What to do
Monitor platelet counts regularly and reduce or hold dalteparin if platelets drop substantially or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Cyclophosphamide with Dalteparin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide can cause thrombocytopenia, which raises bleeding risk in patients receiving the low molecular weight heparin dalteparin. The problem results from combined effects on hemostasis rather than a direct drug interaction.
How serious is the interaction between Cyclophosphamide and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly and reduce or hold dalteparin if platelets drop substantially or bleeding occurs.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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