Drug interactions
Cyclophosphamide + Darunavir
Severity: Moderate
Cyclophosphamide and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may change the conversion of cyclophosphamide to its active and toxic metabolites. The net effect on efficacy and toxicity is unpredictable, and cyclophosphamide is a prodrug activated mainly by CYP2B6 with CYP3A4 contributing to inactivation pathways.
What this interaction means in plain words
Cyclophosphamide and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Darunavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by darunavir and its booster may alter cyclophosphamide metabolism, and ritonavir may also affect CYP2B6.
What to do
Monitor for myelosuppression, infection and signs of urotoxicity or neurotoxicity when the combination is needed. Consider consulting an oncology and HIV pharmacist on the antiretroviral regimen during chemotherapy cycles.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Darunavir?
MediHelp rates the interaction as moderate. Cyclophosphamide and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may change the conversion of cyclophosphamide to its active and toxic metabolites. The net effect on efficacy and toxicity is unpredictable, and cyclophosphamide is a prodrug activated mainly by CYP2B6 with CYP3A4 contributing to inactivation pathways.
How serious is the interaction between Cyclophosphamide and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myelosuppression, infection and signs of urotoxicity or neurotoxicity when the combination is needed. Consider consulting an oncology and HIV pharmacist on the antiretroviral regimen during chemotherapy cycles.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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