Drug interactions
Cyclophosphamide + Fluvoxamine
Severity: Minor
Cyclophosphamide and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits several CYP enzymes including CYP2C19 and CYP1A2 and may reduce CYP2B6 activity, which could decrease activation of cyclophosphamide. The effect on efficacy and toxicity is uncertain and based largely on prediction.
What this interaction means in plain words
Cyclophosphamide and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP-mediated bioactivation of cyclophosphamide by fluvoxamine.
What to do
No routine change is needed; consider an SSRI with less CYP inhibition if concern exists and monitor treatment response and toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Fluvoxamine?
MediHelp rates the interaction as minor. Cyclophosphamide and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine inhibits several CYP enzymes including CYP2C19 and CYP1A2 and may reduce CYP2B6 activity, which could decrease activation of cyclophosphamide. The effect on efficacy and toxicity is uncertain and based largely on prediction.
How serious is the interaction between Cyclophosphamide and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; consider an SSRI with less CYP inhibition if concern exists and monitor treatment response and toxicity.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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