Drug interactions
Cyclophosphamide + Fondaparinux
Severity: Moderate
Cyclophosphamide and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thrombocytopenia from cyclophosphamide adds to the bleeding risk of fondaparinux. Bleeding risk is highest when platelet counts are low or renal function is impaired.
What this interaction means in plain words
Cyclophosphamide and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia combined with factor Xa inhibition.
What to do
Monitor platelet counts and renal function, and hold or reduce fondaparinux when platelets are significantly low or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Cyclophosphamide with Fondaparinux?
MediHelp rates the interaction as moderate. Cyclophosphamide and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thrombocytopenia from cyclophosphamide adds to the bleeding risk of fondaparinux. Bleeding risk is highest when platelet counts are low or renal function is impaired.
How serious is the interaction between Cyclophosphamide and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and renal function, and hold or reduce fondaparinux when platelets are significantly low or bleeding occurs.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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