Drug interactions
Cyclophosphamide + Liposomal doxorubicin
Severity: Moderate
Cyclophosphamide and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are often combined in regimens and have overlapping myelosuppression and cardiotoxicity, with higher cardiac risk at greater cumulative doses. Cyclophosphamide causes hemorrhagic cystitis through its metabolite acrolein, and anthracyclines may add to bladder injury or heighten the risk.
What this interaction means in plain words
Cyclophosphamide and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Additive toxicity from overlapping cytotoxic effects, with cyclophosphamide's acrolein bladder toxicity and cardiotoxicity potentially augmented.
What to do
Ensure good hydration and consider mesna with higher cyclophosphamide doses. Monitor blood counts, cardiac function and urinalysis for hematuria.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Liposomal doxorubicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are often combined in regimens and have overlapping myelosuppression and cardiotoxicity, with higher cardiac risk at greater cumulative doses. Cyclophosphamide causes hemorrhagic cystitis through its metabolite acrolein, and anthracyclines may add to bladder injury or heighten the risk.
How serious is the interaction between Cyclophosphamide and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure good hydration and consider mesna with higher cyclophosphamide doses. Monitor blood counts, cardiac function and urinalysis for hematuria.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
