Drug interactions
Cyclophosphamide + Lonafarnib
Severity: Moderate
Cyclophosphamide and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may change cyclophosphamide metabolism. Because cyclophosphamide activation relies mainly on CYP2B6 with CYP3A4 contribution, the net effect on active metabolite exposure is uncertain but toxicity may change.
What this interaction means in plain words
Cyclophosphamide and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition by lonafarnib alters cyclophosphamide metabolism.
What to do
Monitor blood counts and for signs of cyclophosphamide toxicity or reduced effect. Consider a dose adjustment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Lonafarnib?
MediHelp rates the interaction as moderate. Cyclophosphamide and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may change cyclophosphamide metabolism. Because cyclophosphamide activation relies mainly on CYP2B6 with CYP3A4 contribution, the net effect on active metabolite exposure is uncertain but toxicity may change.
How serious is the interaction between Cyclophosphamide and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of cyclophosphamide toxicity or reduced effect. Consider a dose adjustment if toxicity develops.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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