Drug interactions
Cyclophosphamide + Tecovirimat
Severity: Minor
Cyclophosphamide and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly alter cyclophosphamide metabolism. The effect on active metabolite exposure is probably small and of uncertain clinical significance.
What this interaction means in plain words
Cyclophosphamide and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tecovirimat may modestly change cyclophosphamide metabolism.
What to do
No routine adjustment is needed; monitor clinical response and blood counts as usual during cyclophosphamide treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Cyclophosphamide with Tecovirimat?
MediHelp rates the interaction as minor. Cyclophosphamide and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly alter cyclophosphamide metabolism. The effect on active metabolite exposure is probably small and of uncertain clinical significance.
How serious is the interaction between Cyclophosphamide and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response and blood counts as usual during cyclophosphamide treatment.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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