Drug interactions
Cyclophosphamide + Tipranavir
Severity: Moderate
Cyclophosphamide and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, strongly affects CYP3A4 and may alter cyclophosphamide metabolism. Resulting changes in active metabolite exposure could affect efficacy or toxicity, though the direction and size are uncertain.
What this interaction means in plain words
Cyclophosphamide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir modulates CYP3A4 and other enzymes involved in cyclophosphamide metabolism.
What to do
Monitor blood counts and toxicity during co-therapy. Consider an alternative antiretroviral if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Tipranavir?
MediHelp rates the interaction as moderate. Cyclophosphamide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, strongly affects CYP3A4 and may alter cyclophosphamide metabolism. Resulting changes in active metabolite exposure could affect efficacy or toxicity, though the direction and size are uncertain.
How serious is the interaction between Cyclophosphamide and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and toxicity during co-therapy. Consider an alternative antiretroviral if feasible.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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