Drug interactions
Cyclophosphamide + Trastuzumab deruxtecan
Severity: Moderate
Cyclophosphamide and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause neutropenia, and trastuzumab deruxtecan also carries a risk of interstitial lung disease. Combining them may increase the risk of febrile neutropenia and infection.
What this interaction means in plain words
Cyclophosphamide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Monitor neutrophil counts and signs of infection, and consider growth factor support or dose delay for severe neutropenia. Watch for new respiratory symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Cyclophosphamide with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Cyclophosphamide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause neutropenia, and trastuzumab deruxtecan also carries a risk of interstitial lung disease. Combining them may increase the risk of febrile neutropenia and infection.
How serious is the interaction between Cyclophosphamide and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection, and consider growth factor support or dose delay for severe neutropenia. Watch for new respiratory symptoms.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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