Drug interactions
Cyclophosphamide + Voriconazole
Severity: Moderate
Cyclophosphamide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and CYP2C19, which can shift cyclophosphamide metabolism away from the activation pathway and toward formation of neurotoxic and nephrotoxic metabolites. Both agents may also be hepatotoxic. The direction of the legacy note is the reverse of what is expected.
What this interaction means in plain words
Cyclophosphamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibition of CYP2B6, 2C19 and 3A4 alters cyclophosphamide activation and detoxification.
What to do
Monitor liver function, renal function and neurological status; consider a non-azole antifungal or separate dosing around chemotherapy if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Voriconazole?
MediHelp rates the interaction as moderate. Cyclophosphamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and CYP2C19, which can shift cyclophosphamide metabolism away from the activation pathway and toward formation of neurotoxic and nephrotoxic metabolites. Both agents may also be hepatotoxic. The direction of the legacy note is the reverse of what is expected.
How serious is the interaction between Cyclophosphamide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function, renal function and neurological status; consider a non-azole antifungal or separate dosing around chemotherapy if feasible.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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