Drug interactions
Cyclosporin + Daridorexant
Severity: Moderate
Cyclosporin and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase daridorexant exposure via CYP3A4 inhibition, leading to greater sedation and next-day somnolence or impaired driving.
What this interaction means in plain words
Cyclosporin and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Daridorexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated daridorexant metabolism by cyclosporine.
What to do
Limit daridorexant to 25 mg nightly when used with cyclosporine and counsel patients about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Cyclosporin with Daridorexant?
MediHelp rates the interaction as moderate. Cyclosporin and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase daridorexant exposure via CYP3A4 inhibition, leading to greater sedation and next-day somnolence or impaired driving.
How serious is the interaction between Cyclosporin and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg nightly when used with cyclosporine and counsel patients about next-day drowsiness.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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