Drug interactions
Cyclosporin + Denosumab
Severity: Moderate
Cyclosporin and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect the immune system, and patients on immunosuppressants may be at higher risk of serious infections such as cellulitis with denosumab. Hypocalcemia risk is also higher in patients with renal impairment.
What this interaction means in plain words
Cyclosporin and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Denosumab belongs to Oncology.
Why it happens
Additive immunosuppressive effects; denosumab inhibits RANKL, which also has immune roles.
What to do
Monitor for signs of infection and check serum calcium, ensuring adequate calcium and vitamin D intake.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Cyclosporin with Denosumab?
MediHelp rates the interaction as moderate. Cyclosporin and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents affect the immune system, and patients on immunosuppressants may be at higher risk of serious infections such as cellulitis with denosumab. Hypocalcemia risk is also higher in patients with renal impairment.
How serious is the interaction between Cyclosporin and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check serum calcium, ensuring adequate calcium and vitamin D intake.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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