Drug interactions
Cyclosporin + Dronabinol
Severity: Minor
Cyclosporin and Dronabinol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is highly protein bound, and displacement of other drugs has been proposed but not confirmed in vivo. Cannabinoids may also affect CYP3A4 activity, but the effect on cyclosporine levels is not well defined.
What this interaction means in plain words
Cyclosporin and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Dronabinol belongs to Central Nervous System.
Why it happens
Theoretical protein-binding displacement and possible CYP interaction; not clearly established.
What to do
No routine change is needed; check cyclosporine trough levels if dronabinol is started or the dose changed substantially.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Dronabinol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Cyclosporin with Dronabinol?
MediHelp rates the interaction as minor. Cyclosporin and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronabinol is highly protein bound, and displacement of other drugs has been proposed but not confirmed in vivo. Cannabinoids may also affect CYP3A4 activity, but the effect on cyclosporine levels is not well defined.
How serious is the interaction between Cyclosporin and Dronabinol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check cyclosporine trough levels if dronabinol is started or the dose changed substantially.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
