Drug interactions
Cyclosporin + Elranatamab
Severity: Moderate
Cyclosporin and Elranatamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab triggers cytokine release, which can temporarily suppress CYP450 enzyme activity. This may raise exposure to cyclosporine, a narrow therapeutic index CYP3A4 substrate, and increase the risk of nephrotoxicity and neurotoxicity. The risk is highest during step-up dosing and around cytokine release syndrome episodes.
What this interaction means in plain words
Cyclosporin and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Elranatamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP3A4 activity during cytokine release syndrome reduces cyclosporine metabolism.
What to do
Monitor cyclosporine trough concentrations and renal function during step-up dosing and for about 14 days after, and during any CRS episode. Reduce the cyclosporine dose if levels or toxicity signs rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Cyclosporin with Elranatamab?
MediHelp rates the interaction as moderate. Cyclosporin and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab triggers cytokine release, which can temporarily suppress CYP450 enzyme activity. This may raise exposure to cyclosporine, a narrow therapeutic index CYP3A4 substrate, and increase the risk of nephrotoxicity and neurotoxicity. The risk is highest during step-up dosing and around cytokine release syndrome episodes.
How serious is the interaction between Cyclosporin and Elranatamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function during step-up dosing and for about 14 days after, and during any CRS episode. Reduce the cyclosporine dose if levels or toxicity signs rise.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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