Drug interactions
Cyclosporin + Etonogestrel
Severity: Minor
Cyclosporin and Etonogestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may modestly raise etonogestrel concentrations, which is unlikely to reduce contraceptive efficacy. Progestogens may also affect cyclosporin levels in some patients.
What this interaction means in plain words
Cyclosporin and Etonogestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Etonogestrel belongs to Endocrine.
Why it happens
Cyclosporin inhibits CYP3A4-mediated metabolism of etonogestrel.
What to do
No routine change is needed; monitor cyclosporin levels if hormonal therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Etonogestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Cyclosporin with Etonogestrel?
MediHelp rates the interaction as minor. Cyclosporin and Etonogestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporin may modestly raise etonogestrel concentrations, which is unlikely to reduce contraceptive efficacy. Progestogens may also affect cyclosporin levels in some patients.
How serious is the interaction between Cyclosporin and Etonogestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor cyclosporin levels if hormonal therapy is started or stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
