Drug interactions
Cyclosporin + Fosaprepitant
Severity: Moderate
Cyclosporin and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may modestly raise cyclosporine exposure. Cyclosporine may also raise aprepitant levels. Single-dose use usually has limited effect but cyclosporine's narrow therapeutic index warrants attention.
What this interaction means in plain words
Cyclosporin and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, and cyclosporine inhibits CYP3A4, so each can reduce the other's clearance.
What to do
Monitor cyclosporine trough levels and renal function around fosaprepitant administration, adjusting the dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Cyclosporin with Fosaprepitant?
MediHelp rates the interaction as moderate. Cyclosporin and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may modestly raise cyclosporine exposure. Cyclosporine may also raise aprepitant levels. Single-dose use usually has limited effect but cyclosporine's narrow therapeutic index warrants attention.
How serious is the interaction between Cyclosporin and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function around fosaprepitant administration, adjusting the dose if levels rise.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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