Drug interactions
Cyclosporin + Furosemide
Severity: Moderate
Cyclosporin and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce urate excretion, so combined use increases the risk of hyperuricemia and gout flares. Diuretic-induced volume depletion may also worsen cyclosporin nephrotoxicity.
What this interaction means in plain words
Cyclosporin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Furosemide belongs to Cardiovascular.
Why it happens
Additive impairment of renal urate excretion, with volume depletion potentiating cyclosporin renal toxicity.
What to do
Monitor serum uric acid, creatinine and volume status, and treat hyperuricemia or gout if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Cyclosporin with Furosemide?
MediHelp rates the interaction as moderate. Cyclosporin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce urate excretion, so combined use increases the risk of hyperuricemia and gout flares. Diuretic-induced volume depletion may also worsen cyclosporin nephrotoxicity.
How serious is the interaction between Cyclosporin and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid, creatinine and volume status, and treat hyperuricemia or gout if it occurs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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