Drug interactions
Cyclosporin + Imidapril
Severity: Moderate
Cyclosporin and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors combined with cyclosporine increase the risk of hyperkalemia and acute renal impairment. The risk is greatest with volume depletion or pre-existing renal disease.
What this interaction means in plain words
Cyclosporin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Imidapril belongs to Cardiovascular.
Why it happens
Additive effects on renal hemodynamics and potassium retention, from efferent arteriolar dilation by ACE inhibition and afferent vasoconstriction plus reduced potassium excretion from cyclosporine.
What to do
Monitor serum creatinine and potassium after starting or changing doses and during intercurrent illness. Stop the ACE inhibitor if renal function or potassium worsens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Imidapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Cyclosporin with Imidapril?
MediHelp rates the interaction as moderate. Cyclosporin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors combined with cyclosporine increase the risk of hyperkalemia and acute renal impairment. The risk is greatest with volume depletion or pre-existing renal disease.
How serious is the interaction between Cyclosporin and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and potassium after starting or changing doses and during intercurrent illness. Stop the ACE inhibitor if renal function or potassium worsens significantly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
