Drug interactions
Cyclosporin + Isavuconazole
Severity: Moderate
Cyclosporin and Isavuconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and increases cyclosporine exposure. This may result in cyclosporine toxicity such as nephrotoxicity and hypertension.
What this interaction means in plain words
Cyclosporin and Isavuconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Isavuconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces cyclosporine metabolism.
What to do
Measure cyclosporine trough levels and renal function when starting or stopping isavuconazole, and reduce the cyclosporine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Isavuconazole?
MediHelp rates the interaction as moderate. Cyclosporin and Isavuconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and increases cyclosporine exposure. This may result in cyclosporine toxicity such as nephrotoxicity and hypertension.
How serious is the interaction between Cyclosporin and Isavuconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure cyclosporine trough levels and renal function when starting or stopping isavuconazole, and reduce the cyclosporine dose as needed.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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