Drug interactions
Cyclosporin + Lasmiditan
Severity: Moderate
Cyclosporin and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may raise concentrations of P-gp substrates such as cyclosporine. The clinical significance is uncertain, but cyclosporine has a narrow therapeutic range.
What this interaction means in plain words
Cyclosporin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits intestinal P-glycoprotein, potentially increasing cyclosporine absorption.
What to do
Monitor cyclosporine trough levels and renal function if lasmiditan is used. Consider an alternative migraine therapy in unstable patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Cyclosporin with Lasmiditan?
MediHelp rates the interaction as moderate. Cyclosporin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may raise concentrations of P-gp substrates such as cyclosporine. The clinical significance is uncertain, but cyclosporine has a narrow therapeutic range.
How serious is the interaction between Cyclosporin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function if lasmiditan is used. Consider an alternative migraine therapy in unstable patients.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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