Drug interactions
Cyclosporin + Loperamide
Severity: Moderate
Cyclosporin and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase loperamide absorption and central penetration. At usual doses this is rarely significant, but higher doses may cause CNS or cardiac effects.
What this interaction means in plain words
Cyclosporin and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Cyclosporine inhibits P-glycoprotein and CYP3A4, raising loperamide systemic exposure.
What to do
Use standard loperamide doses and avoid exceeding the recommended maximum. Watch for sedation or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Loperamide
Frequently asked questions
Can I take Cyclosporin with Loperamide?
MediHelp rates the interaction as moderate. Cyclosporin and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase loperamide absorption and central penetration. At usual doses this is rarely significant, but higher doses may cause CNS or cardiac effects.
How serious is the interaction between Cyclosporin and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard loperamide doses and avoid exceeding the recommended maximum. Watch for sedation or palpitations.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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