Drug interactions
Cyclosporin + Nisoldipine
Severity: Major
Cyclosporin and Nisoldipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and can greatly raise nisoldipine concentrations, causing hypotension, edema and tachycardia. Cyclosporine levels may also be affected by calcium channel blockers.
What this interaction means in plain words
Cyclosporin and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Nisoldipine belongs to Cardiovascular.
Why it happens
Cyclosporine inhibits intestinal and hepatic CYP3A4 metabolism of nisoldipine.
What to do
Start with a low nisoldipine dose and titrate by blood pressure, or choose an alternative antihypertensive. Monitor cyclosporine levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Cyclosporin with Nisoldipine?
MediHelp rates the interaction as major. Cyclosporin and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and can greatly raise nisoldipine concentrations, causing hypotension, edema and tachycardia. Cyclosporine levels may also be affected by calcium channel blockers.
How serious is the interaction between Cyclosporin and Nisoldipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low nisoldipine dose and titrate by blood pressure, or choose an alternative antihypertensive. Monitor cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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