Drug interactions
Cyclosporin + Omeprazole
Severity: Moderate
Cyclosporin and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both cyclosporine and long-term proton pump inhibitors can lower serum magnesium, so combined use may increase the risk of hypomagnesemia. Omeprazole may also modestly alter cyclosporine levels in some patients.
What this interaction means in plain words
Cyclosporin and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Additive magnesium loss through renal wasting (cyclosporine) and reduced intestinal absorption (PPIs), with minor CYP-mediated effects.
What to do
Monitor serum magnesium periodically in long-term use and replace as needed. Check cyclosporine trough levels when omeprazole is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Omeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Cyclosporin with Omeprazole?
MediHelp rates the interaction as moderate. Cyclosporin and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both cyclosporine and long-term proton pump inhibitors can lower serum magnesium, so combined use may increase the risk of hypomagnesemia. Omeprazole may also modestly alter cyclosporine levels in some patients.
How serious is the interaction between Cyclosporin and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium periodically in long-term use and replace as needed. Check cyclosporine trough levels when omeprazole is started or stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
