Drug interactions
Cyclosporin + Oxaliplatin
Severity: Moderate
Cyclosporin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair renal function and are immunosuppressive, so combination may increase the risk of renal injury and infection. Reduced oxaliplatin clearance in renal impairment may worsen neurotoxicity and myelosuppression.
What this interaction means in plain words
Cyclosporin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Oxaliplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity and immunosuppression through separate pharmacodynamic effects.
What to do
Monitor serum creatinine and electrolytes before each oxaliplatin cycle and follow cyclosporine levels. Watch for infection and adjust oxaliplatin dose for renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Cyclosporin with Oxaliplatin?
MediHelp rates the interaction as moderate. Cyclosporin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair renal function and are immunosuppressive, so combination may increase the risk of renal injury and infection. Reduced oxaliplatin clearance in renal impairment may worsen neurotoxicity and myelosuppression.
How serious is the interaction between Cyclosporin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes before each oxaliplatin cycle and follow cyclosporine levels. Watch for infection and adjust oxaliplatin dose for renal impairment.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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