Drug interactions
Cyclosporin + Ribociclib
Severity: Major
Cyclosporin and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise cyclosporine concentrations, increasing the risk of nephrotoxicity. Ribociclib itself is a QT-prolonging drug and CYP3A4 substrate.
What this interaction means in plain words
Cyclosporin and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, decreasing cyclosporine metabolism; cyclosporine may also raise ribociclib levels.
What to do
Monitor cyclosporine trough levels and renal function, and reduce cyclosporine dose as needed. Monitor ECG and electrolytes for QT prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ribociclib?
MediHelp rates the interaction as major. Cyclosporin and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib inhibits CYP3A4 and may raise cyclosporine concentrations, increasing the risk of nephrotoxicity. Ribociclib itself is a QT-prolonging drug and CYP3A4 substrate.
How serious is the interaction between Cyclosporin and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and reduce cyclosporine dose as needed. Monitor ECG and electrolytes for QT prolongation.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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