Drug interactions
Golimumab + Rilonacept
Severity: Major
Golimumab and Rilonacept: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining TNF blockade with IL-1 blockade increases the risk of serious infections without added clinical benefit. This has been seen with other biologic combinations such as anakinra with etanercept.
What this interaction means in plain words
Golimumab and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Golimumab belongs to Musculoskeletal; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression from simultaneous inhibition of TNF and IL-1 pathways.
What to do
Avoid combining these biologics. Choose a single agent and monitor for infection if switching between them.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Golimumab with Rilonacept?
MediHelp rates the interaction as major. Golimumab and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining TNF blockade with IL-1 blockade increases the risk of serious infections without added clinical benefit. This has been seen with other biologic combinations such as anakinra with etanercept.
How serious is the interaction between Golimumab and Rilonacept?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining these biologics. Choose a single agent and monitor for infection if switching between them.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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