Drug interactions
Cyclosporin + Rimegepant
Severity: Moderate
Cyclosporin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase rimegepant concentrations. Labeling advises avoiding a repeat dose within 48 hours when rimegepant is taken with P-gp inhibitors.
What this interaction means in plain words
Cyclosporin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Rimegepant belongs to Central Nervous System.
Why it happens
Cyclosporine inhibits P-glycoprotein efflux of rimegepant, increasing its exposure.
What to do
Avoid taking a second rimegepant dose within 48 hours when used with cyclosporine. Consider an alternative migraine treatment if more frequent dosing is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Cyclosporin with Rimegepant?
MediHelp rates the interaction as moderate. Cyclosporin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase rimegepant concentrations. Labeling advises avoiding a repeat dose within 48 hours when rimegepant is taken with P-gp inhibitors.
How serious is the interaction between Cyclosporin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours when used with cyclosporine. Consider an alternative migraine treatment if more frequent dosing is needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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