Drug interactions
Cyclosporin + Saxagliptin
Severity: Minor
Cyclosporin and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin is metabolized by CYP3A4/5, and cyclosporine is a CYP3A4 and P-glycoprotein inhibitor, so exposure to saxagliptin and its active metabolite may rise modestly. Strong inhibitors raise levels more than cyclosporine, and the effect is generally not clinically significant.
What this interaction means in plain words
Cyclosporin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Saxagliptin belongs to Endocrine.
Why it happens
Cyclosporine inhibits CYP3A4/5 and P-glycoprotein, reducing saxagliptin clearance.
What to do
No dose adjustment is normally needed; monitor glycemic control and watch for adverse effects such as hypoglycemia when combined with other agents.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Cyclosporin with Saxagliptin?
MediHelp rates the interaction as minor. Cyclosporin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saxagliptin is metabolized by CYP3A4/5, and cyclosporine is a CYP3A4 and P-glycoprotein inhibitor, so exposure to saxagliptin and its active metabolite may rise modestly. Strong inhibitors raise levels more than cyclosporine, and the effect is generally not clinically significant.
How serious is the interaction between Cyclosporin and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed; monitor glycemic control and watch for adverse effects such as hypoglycemia when combined with other agents.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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