Drug interactions
Cyclosporin + Solifenacin
Severity: Minor
Cyclosporin and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase solifenacin concentrations, increasing anticholinergic effects such as dry mouth, constipation, urinary retention and QT prolongation. The effect is mostly predicted from CYP3A4 inhibition.
What this interaction means in plain words
Cyclosporin and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Solifenacin belongs to Genitourinary.
Why it happens
Cyclosporine inhibits CYP3A4-mediated solifenacin metabolism.
What to do
Monitor for anticholinergic effects and reduce the solifenacin dose if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Solifenacin
Frequently asked questions
Can I take Cyclosporin with Solifenacin?
MediHelp rates the interaction as minor. Cyclosporin and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may increase solifenacin concentrations, increasing anticholinergic effects such as dry mouth, constipation, urinary retention and QT prolongation. The effect is mostly predicted from CYP3A4 inhibition.
How serious is the interaction between Cyclosporin and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce the solifenacin dose if they become troublesome.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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