Drug interactions
Cyclosporin + Tolebrutinib
Severity: Moderate
Cyclosporin and Tolebrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolebrutinib may increase cyclosporin exposure through transporter inhibition. Higher levels raise the risk of nephrotoxicity and other cyclosporin toxicities.
What this interaction means in plain words
Cyclosporin and Tolebrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Tolebrutinib belongs to Central Nervous System.
Why it happens
Inhibition of drug transporters such as P-glycoprotein may increase cyclosporin absorption and reduce elimination.
What to do
Monitor cyclosporin trough concentrations and renal function, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolebrutinib
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Tolebrutinib?
MediHelp rates the interaction as moderate. Cyclosporin and Tolebrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolebrutinib may increase cyclosporin exposure through transporter inhibition. Higher levels raise the risk of nephrotoxicity and other cyclosporin toxicities.
How serious is the interaction between Cyclosporin and Tolebrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporin trough concentrations and renal function, and adjust the dose accordingly.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Efavirenz. The full list is on the Tolebrutinib page.
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