Drug interactions
Letermovir + Tolebrutinib
Severity: Major
Letermovir and Tolebrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can inhibit CYP2C8 and raise tolebrutinib concentrations while lowering M2. This may increase the risk of tolebrutinib adverse effects, notably liver injury.
What this interaction means in plain words
Letermovir and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Letermovir belongs to Anti Virals; Tolebrutinib belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 reduces tolebrutinib clearance.
What to do
Avoid concomitant use where possible. If letermovir prophylaxis is needed, consider withholding tolebrutinib or monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolebrutinib
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Tolebrutinib?
MediHelp rates the interaction as major. Letermovir and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir can inhibit CYP2C8 and raise tolebrutinib concentrations while lowering M2. This may increase the risk of tolebrutinib adverse effects, notably liver injury.
How serious is the interaction between Letermovir and Tolebrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If letermovir prophylaxis is needed, consider withholding tolebrutinib or monitor liver tests closely.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Efavirenz. The full list is on the Tolebrutinib page.
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