Drug interactions
Efavirenz + Tolebrutinib
Severity: Major
Efavirenz and Tolebrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is an inducer of CYP3A and can reduce tolebrutinib concentrations, potentially weakening its effect.
What this interaction means in plain words
Efavirenz and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Tolebrutinib belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases tolebrutinib clearance.
What to do
Avoid long-term combination and consider a non-inducing antiretroviral regimen. Short exposure under two weeks does not require interruption of tolebrutinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolebrutinib
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Tolebrutinib?
MediHelp rates the interaction as major. Efavirenz and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz is an inducer of CYP3A and can reduce tolebrutinib concentrations, potentially weakening its effect.
How serious is the interaction between Efavirenz and Tolebrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination and consider a non-inducing antiretroviral regimen. Short exposure under two weeks does not require interruption of tolebrutinib.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Gemfibrozil. The full list is on the Tolebrutinib page.
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