Drug interactions
Gemfibrozil + Tolebrutinib
Severity: Major
Gemfibrozil and Tolebrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil strongly inhibits CYP2C8, a pathway contributing to tolebrutinib metabolism. Tolebrutinib exposure increases and formation of its M2 metabolite falls, which may raise adverse effects such as liver injury.
What this interaction means in plain words
Gemfibrozil and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemfibrozil belongs to Cardiovascular; Tolebrutinib belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 (also by gemfibrozil glucuronide) reduces tolebrutinib clearance.
What to do
Avoid concomitant use and select another lipid-lowering agent such as a statin. If it cannot be avoided, monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gemfibrozil and Tolebrutinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolebrutinib
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Tolebrutinib?
MediHelp rates the interaction as major. Gemfibrozil and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil strongly inhibits CYP2C8, a pathway contributing to tolebrutinib metabolism. Tolebrutinib exposure increases and formation of its M2 metabolite falls, which may raise adverse effects such as liver injury.
How serious is the interaction between Gemfibrozil and Tolebrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select another lipid-lowering agent such as a statin. If it cannot be avoided, monitor liver tests closely.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Efavirenz. The full list is on the Tolebrutinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
