Drug interactions
Cyclosporin + Trofinetide
Severity: Moderate
Cyclosporin and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor and could modestly increase cyclosporine concentrations. Because cyclosporine has a narrow therapeutic index, this may increase toxicity.
What this interaction means in plain words
Cyclosporin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Trofinetide belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 reduces cyclosporine metabolism.
What to do
Monitor cyclosporine trough concentrations and renal function after starting trofinetide. Adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Cyclosporin with Trofinetide?
MediHelp rates the interaction as moderate. Cyclosporin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide is a weak CYP3A4 inhibitor and could modestly increase cyclosporine concentrations. Because cyclosporine has a narrow therapeutic index, this may increase toxicity.
How serious is the interaction between Cyclosporin and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function after starting trofinetide. Adjust the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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