Drug interactions
Cyclosporine + Entecavir
Severity: Moderate
Cyclosporine and Entecavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can reduce renal function, which may increase entecavir exposure because entecavir is renally eliminated. The effect is usually modest, though the combination is common in transplant patients.
What this interaction means in plain words
Cyclosporine and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine-related reduction in glomerular filtration may decrease renal clearance of entecavir.
What to do
Monitor renal function regularly and adjust the entecavir dose or interval according to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entecavir
Frequently asked questions
Can I take Cyclosporine with Entecavir?
MediHelp rates the interaction as moderate. Cyclosporine and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can reduce renal function, which may increase entecavir exposure because entecavir is renally eliminated. The effect is usually modest, though the combination is common in transplant patients.
How serious is the interaction between Cyclosporine and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function regularly and adjust the entecavir dose or interval according to creatinine clearance.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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