Drug interactions
Cidofovir + Entecavir
Severity: Moderate
Cidofovir and Entecavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by the kidney including active tubular secretion, so they may raise each other's levels. Cidofovir's nephrotoxicity could further reduce entecavir clearance. The practical significance is uncertain.
What this interaction means in plain words
Cidofovir and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cidofovir belongs to Anti Virals; Entecavir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion and cidofovir-related reduction in renal function.
What to do
Monitor renal function and adjust the entecavir dose according to creatinine clearance if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Entecavir
Frequently asked questions
Can I take Cidofovir with Entecavir?
MediHelp rates the interaction as moderate. Cidofovir and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated by the kidney including active tubular secretion, so they may raise each other's levels. Cidofovir's nephrotoxicity could further reduce entecavir clearance. The practical significance is uncertain.
How serious is the interaction between Cidofovir and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust the entecavir dose according to creatinine clearance if renal function worsens.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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