Drug interactions
Canagliflozin-metformin + Entecavir
Severity: Moderate
Canagliflozin-metformin and Entecavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir labeling warns of lactic acidosis with nucleoside analogues, and metformin independently carries this risk. Combined use may add to the risk, particularly with renal impairment or liver disease.
What this interaction means in plain words
Canagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
Why it happens
Both drugs can impair lactate metabolism, via mitochondrial toxicity for entecavir and inhibited gluconeogenesis for metformin, giving additive risk.
What to do
Monitor renal function and watch for symptoms of lactic acidosis such as malaise, abdominal pain and hyperventilation. Stop therapy and check lactate if these develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
- Empagliflozin-metformin + Entecavir Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir labeling warns of lactic acidosis with nucleoside analogues, and metformin independently carries this risk. Combined use may add to the risk, particularly with renal impairment or liver disease.
How serious is the interaction between Canagliflozin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for symptoms of lactic acidosis such as malaise, abdominal pain and hyperventilation. Stop therapy and check lactate if these develop.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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