Drug interactions
Dapagliflozin-metformin + Entecavir
Severity: Moderate
Dapagliflozin-metformin and Entecavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir and metformin have both been linked to lactic acidosis, and entecavir labeling notes this risk, particularly in patients with hepatic or renal impairment. Using them together may add to that risk.
What this interaction means in plain words
Dapagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
Why it happens
Additive risk of lactic acidosis, possibly via mitochondrial toxicity with entecavir and impaired lactate clearance with metformin.
What to do
Monitor for symptoms of lactic acidosis and check renal and hepatic function regularly. Stop metformin if lactic acidosis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
- Empagliflozin-metformin + Entecavir Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir and metformin have both been linked to lactic acidosis, and entecavir labeling notes this risk, particularly in patients with hepatic or renal impairment. Using them together may add to that risk.
How serious is the interaction between Dapagliflozin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of lactic acidosis and check renal and hepatic function regularly. Stop metformin if lactic acidosis is suspected.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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