Drug interactions
Empagliflozin-metformin + Entecavir
Severity: Moderate
Empagliflozin-metformin and Entecavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir carries a labeled warning for lactic acidosis, and metformin also carries this risk. Using both may add to the risk, particularly with renal impairment or hepatic disease.
What this interaction means in plain words
Empagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
Why it happens
Additive risk of lactic acidosis, with entecavir possibly impairing mitochondrial function; no established pharmacokinetic interaction.
What to do
Monitor renal and hepatic function and watch for symptoms of lactic acidosis such as malaise, myalgia and rapid breathing. Stop metformin if lactic acidosis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Frequently asked questions
Can I take Empagliflozin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir carries a labeled warning for lactic acidosis, and metformin also carries this risk. Using both may add to the risk, particularly with renal impairment or hepatic disease.
How serious is the interaction between Empagliflozin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal and hepatic function and watch for symptoms of lactic acidosis such as malaise, myalgia and rapid breathing. Stop metformin if lactic acidosis is suspected.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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