Drug interactions
Cyclosporine + Hydrochlorothiazide-irbesartan
Severity: Moderate
Cyclosporine and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can cause hyperkalemia, hypertension, and nephrotoxicity, and irbesartan may add to potassium retention and reduced glomerular filtration. Thiazides raise uric acid and may worsen cyclosporine-related hyperuricemia and gout. Renal function can deteriorate when these are combined.
What this interaction means in plain words
Cyclosporine and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on renal haemodynamics and potassium handling, with cyclosporine-induced renal vasoconstriction and ARB-mediated efferent dilation.
What to do
Monitor serum potassium, creatinine, and blood pressure regularly, and check uric acid when clinically relevant. Adjust therapy if hyperkalemia or declining renal function develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Cyclosporine with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Cyclosporine and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can cause hyperkalemia, hypertension, and nephrotoxicity, and irbesartan may add to potassium retention and reduced glomerular filtration. Thiazides raise uric acid and may worsen cyclosporine-related hyperuricemia and gout. Renal function can deteriorate when these are combined.
How serious is the interaction between Cyclosporine and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine, and blood pressure regularly, and check uric acid when clinically relevant. Adjust therapy if hyperkalemia or declining renal function develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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