Drug interactions
Cyproheptadine + Daridorexant
Severity: Moderate
Cyproheptadine and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system. Together they can intensify sleepiness and impair next-day alertness, coordination and driving ability.
What this interaction means in plain words
Cyproheptadine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Daridorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and orexin receptor blockade.
What to do
Counsel the patient about daytime impairment and avoid driving until response is known. Consider reducing the daridorexant dose or stopping cyproheptadine if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Cyproheptadine with Daridorexant?
MediHelp rates the interaction as moderate. Cyproheptadine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system. Together they can intensify sleepiness and impair next-day alertness, coordination and driving ability.
How serious is the interaction between Cyproheptadine and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about daytime impairment and avoid driving until response is known. Consider reducing the daridorexant dose or stopping cyproheptadine if sedation is excessive.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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