Drug interactions
Cyproheptadine + Desflurane
Severity: Moderate
Cyproheptadine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines may add to the central depressant effects of inhalational anesthetics such as desflurane. This can prolong recovery and deepen sedation perioperatively.
What this interaction means in plain words
Cyproheptadine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Desflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Inform the anesthesia team about cyproheptadine use and titrate anesthetic depth to effect, with monitoring of recovery and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Desflurane
Frequently asked questions
Can I take Cyproheptadine with Desflurane?
MediHelp rates the interaction as moderate. Cyproheptadine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines may add to the central depressant effects of inhalational anesthetics such as desflurane. This can prolong recovery and deepen sedation perioperatively.
How serious is the interaction between Cyproheptadine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about cyproheptadine use and titrate anesthetic depth to effect, with monitoring of recovery and respiratory status.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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