Drug interactions
Cyproheptadine + Dexchlorpheniramine
Severity: Moderate
Cyproheptadine and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation antihistamines, so combining them duplicates therapy and adds to sedation and anticholinergic effects. Dry mouth, urinary retention, confusion and drowsiness are more likely.
What this interaction means in plain words
Cyproheptadine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive H1 antagonism with CNS depressant and anticholinergic effects.
What to do
Avoid using two sedating antihistamines together and choose a single agent. Monitor elderly patients for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Cyproheptadine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Cyproheptadine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation antihistamines, so combining them duplicates therapy and adds to sedation and anticholinergic effects. Dry mouth, urinary retention, confusion and drowsiness are more likely.
How serious is the interaction between Cyproheptadine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two sedating antihistamines together and choose a single agent. Monitor elderly patients for anticholinergic toxicity.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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