Drug interactions
Cyproheptadine + Difelikefalin
Severity: Moderate
Cyproheptadine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and cyproheptadine adds sedating antihistamine effects. Together they may increase drowsiness and the risk of falls, especially in dialysis patients.
What this interaction means in plain words
Cyproheptadine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depression from kappa-opioid receptor agonism and H1 receptor antagonism.
What to do
Monitor for excessive sedation, dizziness and falls. Consider reducing the cyproheptadine dose or choosing a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Cyproheptadine with Difelikefalin?
MediHelp rates the interaction as moderate. Cyproheptadine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and cyproheptadine adds sedating antihistamine effects. Together they may increase drowsiness and the risk of falls, especially in dialysis patients.
How serious is the interaction between Cyproheptadine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls. Consider reducing the cyproheptadine dose or choosing a non-sedating antihistamine.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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