Drug interactions
Cyproheptadine + Eluxadoline
Severity: Moderate
Cyproheptadine and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline can cause constipation and, rarely, pancreatitis or serious bowel complications. Cyproheptadine has anticholinergic properties that reduce gut motility and may add to constipation.
What this interaction means in plain words
Cyproheptadine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive reduction in gastrointestinal motility from mu-opioid agonism and anticholinergic activity.
What to do
Avoid combining with other constipating drugs where possible. If used together, monitor bowel function and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyproheptadine and Eluxadoline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Cyproheptadine with Eluxadoline?
MediHelp rates the interaction as moderate. Cyproheptadine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline can cause constipation and, rarely, pancreatitis or serious bowel complications. Cyproheptadine has anticholinergic properties that reduce gut motility and may add to constipation.
How serious is the interaction between Cyproheptadine and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with other constipating drugs where possible. If used together, monitor bowel function and stop eluxadoline if severe constipation develops.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
