Drug interactions
Cyproheptadine + Etomidate
Severity: Moderate
Cyproheptadine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and a sedating antihistamine such as cyproheptadine may add to its depressant effects. This is mostly relevant in the perioperative setting, where deeper or prolonged sedation could occur.
What this interaction means in plain words
Cyproheptadine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 antagonism.
What to do
Inform the anesthesia team of recent cyproheptadine use. Titrate etomidate to effect and monitor sedation depth and ventilation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Cyproheptadine with Etomidate?
MediHelp rates the interaction as moderate. Cyproheptadine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent, and a sedating antihistamine such as cyproheptadine may add to its depressant effects. This is mostly relevant in the perioperative setting, where deeper or prolonged sedation could occur.
How serious is the interaction between Cyproheptadine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent cyproheptadine use. Titrate etomidate to effect and monitor sedation depth and ventilation.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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