Drug interactions
Cyproheptadine + Flibanserin
Severity: Moderate
Cyproheptadine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin causes sedation, somnolence and hypotension, and the effect is increased by other CNS depressants such as sedating antihistamines. Cyproheptadine may also theoretically blunt flibanserin's serotonergic activity.
What this interaction means in plain words
Cyproheptadine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression, with possible pharmacodynamic opposition at serotonin receptors.
What to do
Counsel on increased drowsiness and avoid dosing close together at bedtime if sedation is excessive. Monitor for dizziness and reduced efficacy, and consider an alternative non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Flibanserin?
MediHelp rates the interaction as moderate. Cyproheptadine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin causes sedation, somnolence and hypotension, and the effect is increased by other CNS depressants such as sedating antihistamines. Cyproheptadine may also theoretically blunt flibanserin's serotonergic activity.
How serious is the interaction between Cyproheptadine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on increased drowsiness and avoid dosing close together at bedtime if sedation is excessive. Monitor for dizziness and reduced efficacy, and consider an alternative non-sedating antihistamine.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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