Drug interactions
Cyproheptadine + Fluvoxamine
Severity: Moderate
Cyproheptadine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine blocks serotonin receptors and may weaken the therapeutic effect of SSRIs, including fluvoxamine. The effect would be expected mainly with sustained co-use.
What this interaction means in plain words
Cyproheptadine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Fluvoxamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of 5-HT2A receptors by cyproheptadine opposes SSRI serotonergic effects.
What to do
Monitor for return of depressive or obsessive-compulsive symptoms. Avoid prolonged co-use where an alternative antihistamine is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Fluvoxamine?
MediHelp rates the interaction as moderate. Cyproheptadine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine blocks serotonin receptors and may weaken the therapeutic effect of SSRIs, including fluvoxamine. The effect would be expected mainly with sustained co-use.
How serious is the interaction between Cyproheptadine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for return of depressive or obsessive-compulsive symptoms. Avoid prolonged co-use where an alternative antihistamine is suitable.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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