Drug interactions
Cyproheptadine + Haloperidol
Severity: Moderate
Cyproheptadine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, and cyproheptadine adds anticholinergic effects to haloperidol's CNS depression. Patients may experience drowsiness, impaired coordination and confusion, especially if elderly.
What this interaction means in plain words
Cyproheptadine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor sedation, cognition and anticholinergic effects, and counsel about driving and machinery. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Haloperidol?
MediHelp rates the interaction as moderate. Cyproheptadine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, and cyproheptadine adds anticholinergic effects to haloperidol's CNS depression. Patients may experience drowsiness, impaired coordination and confusion, especially if elderly.
How serious is the interaction between Cyproheptadine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, cognition and anticholinergic effects, and counsel about driving and machinery. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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