Drug interactions
Cyproheptadine + Hydroxyzine
Severity: Moderate
Cyproheptadine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating first-generation antihistamines with anticholinergic activity. Combined use raises the risk of drowsiness, confusion, dry mouth, urinary retention and constipation, especially in older people.
What this interaction means in plain words
Cyproheptadine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive H1 antihistamine sedation and antimuscarinic effects.
What to do
Avoid duplicate antihistamine therapy where possible. If both are needed, use the lowest doses and monitor sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Cyproheptadine with Hydroxyzine?
MediHelp rates the interaction as moderate. Cyproheptadine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating first-generation antihistamines with anticholinergic activity. Combined use raises the risk of drowsiness, confusion, dry mouth, urinary retention and constipation, especially in older people.
How serious is the interaction between Cyproheptadine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antihistamine therapy where possible. If both are needed, use the lowest doses and monitor sedation and anticholinergic effects.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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